Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ
Estimates by Ray Peat, PhD: “The brand new proportion out of calcium supplements so you can phosphate is important; this is why whole milk and you may parmesan cheese are beneficial for losing weight, and preventing putting on weight. For many who commonly really effective, zero fat dairy and you can cheese be more effective, because the extra fat unhealthy calories commonly expected.”
“The meals large from inside the phosphate, in accordance with calcium, was cereals, beans, chicken, and you may fish. Of several waiting dinners include additional phosphate. Food which have increased, safer ratio off calcium in order to phosphate are simply leaves, such as for instance kale, turnip greens, and you can beet veggies, and some good fresh fruit, milk products, and you can cheese.”
Br J Nutr
“Free unsaturated efas stimulate pressure hormones, and you may cortisol reduces oxidization out-of sugar and you may turns they to your greasy acids and you can triglycerides. Keeping cortisol and you can worry lowest is the head topic. Remaining a high ratio regarding calcium supplements so you’re able to phosphate really helps to oppose the stress metabolism.” “Current publication are showing you to too much phosphate can increase soreness, tissues atrophy, calcification out of blood vessels, cancer, alzhiemer’s disease, and you can, typically, the new processes out-of aging.”
2006 Sep;96(3):545-52. Highest phosphorus intakes incredibly and you may negatively apply to Ca and bones kcalorie burning within the a serving-created trends in the match young female. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. Ca and P is each other essential nutrients to possess limbs and are also recognized to apply at probably one of the most extremely important authorities off limbs metabolism, parathyroid hormone (PTH). Also reasonable a good P intake, normal away from West diet, might be deleterious so you’re able to bone from the enhanced PTH hormonal. Couples controlled dose-reaction studies are on the results out of high P consumption into the guy. We learned the fresh new small-label ramifications of four P dosages into Ca and you will bone k-calorie burning in fourteen match females, 20-28 years of age, have been randomized to help you four regulated data days; thus for each study subject served just like the her own control. P enhance dosage off 0 (placebo), 250, 750 otherwise 1500 milligrams was drawn, split into about three dosage within the investigation go out. The meals served were alike during for every single analysis day and you will given 495 milligrams P and you may 250 milligrams Ca. The new P dosages affected the new serum PTH (S-PTH) when you look at the an amount-dependent style (P=0.0005). There’s a decrease in solution ionized California concentration simply within the the greatest P serving (P=0.004). Brand new marker off bone formation, bone-certain alkaline phosphatase, reduced (P=0.05) additionally the bone resorption marker, N-terminal telopeptide out of collagen particular I, increased in response into the P amounts (P=0.05). So it regulated serving-reaction data showed that P have a dosage-based impact on S-PTH and grows PTH hormonal rather whenever California consumption try lowest. Excessively large P consumption adversely affects bones k-calorie burning by decreasing bones formation and you may broadening bone resorption, since conveyed from the bone metabolism indicators.
20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.